Faculty Profile

Name

Shu-Hao Chang, Ph.D.

Position

Assistant Professor (Full-Time)

Education

Ph.D., Institute of Clinical Medicine, National Yang Ming Chiao Tung University

M.S., Institute of Biomedical Sciences, National Chung Hsing University

B.S., Department of Life Sciences, National University of Kaohsiung

Professional Experience

Postdoctoral Research Fellow, Institute of Biomedical Sciences, National Chung Hsing University

Contract Assistant Researcher, Institute of Biomedical Sciences, National Chung Hsing University

Research Expertise/ Specialty

Tumor Cell Biology; Dermatological Sciences; Tumor Immunology; Cell Death; Mouse Disease Models

Office

Room 609, College of Science Building

Laboratory

Cancer Translational Medicine and Immunoregulation Laboratory (CTMI Lab)

Room 609-1, College of Science Building

Contact Information

Tel: +886-7-591-9467 ext. 7467

Fax: +886-7-591-9404

E-mail: shchang0501@nuk.edu.tw

Research Interests

My research focuses on the molecular mechanisms of clinically induced cancer cell death and its crosstalk with immune responses. A major emphasis of my work is drug repurposing for cancer therapy, including the identification and development of novel anticancer strategies using existing drugs.

Using molecular and cellular biology approaches in combination with experimental animal models, my research investigates the molecular mechanisms and signaling pathways underlying clinically used anticancer drug–induced cancer cell death. Complementary strategies are further employed to enhance the therapeutic efficacy of anticancer agents. The major research platforms include apoptosis, autophagy, immunogenic cell death, lysosome-dependent cell death, and ferroptosis. Experimental animal platforms include mouse disease models of skin cancer, breast cancer, and liver cancer, as well as mouse models of ulcerative colitis and psoriasis.

The laboratory (Room 609) provides the following technical platforms and research capabilities:

1. Cell death research platforms

2. Cellular oxidative stress detection and analysis

3. Quantitative and functional analysis of mitochondria and lysosomes

4. Macrophage differentiation platform

5. In situ mouse disease models of skin cancer, breast cancer, and liver cancer, as well as mouse models of ulcerative colitis and psoriasis

Courses Taught

Undergraduate: Stem Cell Technology and Applications

Graduate: Seminar (I); Special Topics in Molecular Biology; Special Topics in Immunology and Disease